For one of our clients, and international pharma company in Basel, we are looking for aGenetics & Genomics Lab research associate.
In this role you will play a key role in the development and implementation of genomic assays for biomarker analysis in both pre-clinical and clinical settings. Your primary responsibility will be hands-on laboratory work, driving innovation and advancing our understanding of genetic and genomic mechanisms in support of therapeutic development.
General Information:
* Start date: ASAP
* Latest start date: February 2025
* Planned duration: 2 years
* Extension: possible
* Workplace: Basel
* Workload: 100%
* Remote/Home Office: occasionallypossible
* Travel: no
* Team: 25
* Working hours: Standard
Tasks & Responsibilities:
* Develop, validate, and implement genetics and genomics-based biomarker assays (e.g., epigenetics, SNVs, CNVs, gene expression signatures, circulating DNA/RNA) to support pre-clinical studies and early-phase clinical trials, characterizing pharmacodynamics and mechanisms of action for novel therapeutics.
* Evaluate and apply cutting-edge genetics and genomics technologies (e.g., single-cell sequencing, spatial-omics, ddPCR) to maximize insights from limited and valuable pre-clinical and clinical samples followingGCP standards
* Deliver high-quality biomarker data to project biology and biomarker teams, ensuring impactful contributions to therapeutic development.
* Ensure compliance with Safety, Health, and Environment (SHE) regulations in all laboratory and operational activities, contributing to a safe and sustainable research environment.
* Inspire and train other scientists and associates in applying novel technologies and facilitate the transfer of innovative methods to external collaboration partners.
Must Haves:
* Master's degree or higher in molecular biology, biochemistry, or a related field with substantial experience in biomarker assay development in pre-clinical or clinical settings.
* Deep hands-on expertise in molecular biology techniques (e.g., qPCR, ddPCR) and next-generation sequencing (NGS) platforms, including single-cell and spatial-omics technologies.
* Proficiency in developing, validating, and applying genomic assays across multiple platforms and sample types (e.g., tissue, liquid biopsies).
* Familiarity with implementing genetics and genomics assays in compliance with Good Clinical Practices (GCP) is a plus.
* Fluency in English is required, German would be nice to have
* Ability to think creatively and rigorously in evaluating and developing new technologies for current and emerging scientific modalities.
* Strong focus on ensuring operational compliance in the storage e.g. tracking, and management of samples and data, adhering to established regulatory and organizational standards.
* Strong team player with a collaborative spirit, able to work independently and within agile, matrixed teams.
Nice to Have:
* Previous Pharma experience
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