At Roche, you can show up as yourself, valued for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections, where you are respected for who you are.
The Position
We believe it's urgent to deliver medical solutions right now – even as we develop innovations for the future. We are passionate about transforming patients' lives and fearless in both decision and action. Good business means a better world.
About the Opportunity
We are seeking a highly motivated postdoctoral fellow to join the Immunology Discovery group of the Cardiovascular Metabolism and Immunology Department. The research project will investigate the role of T cell plasticity in maintaining intestinal homeostasis and the development of chronic and tissue-damaging intestinal inflammation.
Your Responsibilities:
* Analyze multi-omics data sets, including scRNAseq, TCRseq, 16Sseq, and metabolomics, to identify molecules to be tested in vitro;
* Develop methods for isolating immune cells from blood and tissue;
* Perform detailed immune phenotyping using multicolor flow cytometry;
* Conduct sophisticated in vitro 3D cultures, including organoids, of human and mouse cells;
* Investigate the impact of bacterial isolates and/or metabolites on host immune, epithelial, and stromal cells;
* Carry out in vivo studies to further mechanistic understanding;
About You:
To be successful in this position, you should have a PhD in immunology obtained no longer than four years ago, a profound understanding of human immunology, mucosal immunity, and T cell biology, extensive experience with state-of-the-art flow cytometry, including FACS, and hands-on experience with isolation and cultivation of human immune cells.
About Roche
We strive to build a team that represents a variety of backgrounds, perspectives, and skills. A healthier future drives us to innovate, and together, more than 100,000 employees across the globe are dedicated to advancing science and ensuring everyone has access to healthcare today and for generations to come.