Principal Scientist I - si RNA (80-100%*)Job ID REQ-10043484 Mar 07, 2025 Summary Location: Basel, Switzerland Fulltime, onsite, #LIonsite We are seeking a highly motivated and curious Principal Scientist whose focus will be on si RNA discovery in the x RNA Team within Biomedical Research based in Basel. The team develops next-generation x RNA therapeutics in a collaborative and innovation-driven environment, aiming to transform the lives of millions of patients with unmet medical needs. The successful candidate will have strong experience in si RNA biology and/or therapeutics and will have a key role in driving the development of the x RNA platform and mentoring Lab team members. About the Role Key Responsibilities: Lead matrix-oriented platform teams for the development of si RNA therapeutics Experience with end-to-end NGS experiments including library preparation, sequencing, and analysis Drive innovation based on data mining from hypothesis generation to conduct studies in a collaborative environment across Biomedical Research Design, plan and supervise si RNA cell-based screening activities Perform novel assay development and optimization for cell-based assays with a focus on improving throughput with automation With supervision lead junior scientists in the lab and with data analysis Represent x RNA team on cross-functional project teams to advance si RNA programs through the development pipeline Document experiments in lab notebook, conduct data analysis, interpretation and present findings to team in a timely manner Role Requirements: Ph D in biochemistry or biology or related scientific discipline3 - 5 years of post-Ph D research experience gained in academia as a Postdoc and/or in industry Research experience in si RNA biology. Knowledge of si RNA therapeutics would be an advantage. Strong genomics background with expertise in RNA-Seq from experiment to data processing Able to run R scripts independently Expertise in mammalian cell culture from immortalized to primary cells Experience with cross-functional teams and ability to serve as a point of contact for the team with minimal supervision Strong multi-tasking, organizational, attention to detail, verbal/written communication skills Ability to collaborate and thrive in fast-paced, team-oriented environment Desired Requirements: Expertise with Bio Mek or Opentrons liquid handlers Proficient in R and/or Python. Machine Learning experience a plus.*Restrictions on working flexibility may apply to this position and can be discussed at interview as required. Accessibility and accommodation: Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to inclusion.switzerland@novartis.com and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? Learn more. Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: Join here. Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve.
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