About Us
Siegfried DINAMIQS is a Contract Development and Manufacturing Organization (CDMO) based in Switzerland, specializing in the manufacturing of viral vector gene therapies.
We are at the forefront of science and innovation, helping our clients improve outcomes and accelerate their gene therapy projects. Our comprehensive range of services includes vector design optimization, cutting-edge process development and analytics, as well as manufacturing. With state-of-the-art R&D facilities and a new GMP facility, we support gene therapy projects with scalable and efficient solutions.
As part of Siegfried's global network since 2023, we are now looking to grow our team of experts by hiring a GMP Upstream Process Supervisor. This role reports directly to the Head of Manufacturing and offers the chance to shape the future of gene therapy together with our team and clients.
This position requires a highly motivated, entrepreneurial, outcome-driven individual eager to advance state-of-the-art gene therapy.
Your responsibilities will include:
* Performing GMP Upstream operations, including mammalian cell culture, bioreactor management, and aseptic techniques for cell line handling.
* Managing buffer and media preparation, powders, and liquids for internal supply, ensuring compliance with GMP standards.
* Handling single-use technologies, including materials management, closed systems, and aseptic connectors, welding, and sealing.
* Contributing to technology transfer and scale-up processes as needed.
* Preparing, reviewing, and managing GMP documentation, including manufacturing batch records, SOPs, and risk analyses, with an emphasis on electronic batch records and paperless environments.
* Troubleshooting and resolving upstream manufacturing issues, conducting root cause analysis, and planning sector activities effectively.
* Adapting to new technologies and implementing innovative methods to enhance efficiency and production effectiveness.
* Managing timelines and resources to meet company milestones, while providing training and guidance to staff on operational and compliance procedures.
Requirements
Expertise
* Degree in biotechnology, bioprocess engineering, or related field.
* 3-5 years of experience in pilot or commercial production of biotechnological products in the USP sector; experience with Advanced Therapies Medicinal Products is a plus.
* Familiarity with QbD, cGMP, and commercial manufacturing requirements; experience in process and equipment qualification is desirable.
* Proficient in Sartorius BioPat MFCS software, SCADA interfaces, and Microsoft Office Suite.
* Experience in equipment and process qualification and validation from a production perspective.
* Fluent in English; German is a plus.
Personal Skills
* Strong organizational skills, detail-oriented, and capable of working autonomously to meet timelines.
* Effective problem-solving skills, including troubleshooting and root cause analysis for manufacturing issues.
* Excellent communication and collaboration skills, with the ability to represent the sector in cross-functional forums.
* Adaptable to evolving technologies and processes, with a focus on innovation and continuous improvement.
* Team-oriented mindset.
What We Offer
* A unique and amazing work experience, being part of one of the most dynamic, diverse, and inclusive CDMOs in the industry.
* Competitive and attractive compensation, including an STI component.
* 5 weeks holidays and flexible working hours make it possible to combine family, leisure time, and career.
* Impactful Work: Make a significant difference through innovative gene therapy projects.
* Learning Opportunities: Develop diverse skills in a dynamic environment.
* Fast-Paced Environment: See results quickly and enjoy creative freedom.