Key Responsibilities:
* In Vivo Studies: Plan, design, and execute in vivo pharmacology experiments using animal models to evaluate the effects of drug candidates on physiological and pathological processes.
* Pharmacokinetics & Pharmacodynamics: Perform pharmacokinetic (PK) and pharmacodynamic (PD) assessments, including dosing regimens, bioanalysis, and measurement of drug concentrations in biological fluids and tissues.
* Efficacy Evaluation: Assess the therapeutic potential of drug candidates by conducting efficacy studies in relevant animal models of disease, including tumor models, inflammation, cardiovascular, and metabolic diseases.
* Safety and Toxicology: Collaborate with toxicologists to assess the safety profile of drug candidates by performing acute, subchronic, and chronic toxicity studies.
* Data Analysis and Reporting: Analyze data from in vivo studies, prepare detailed reports, and communicate findings effectively with multidisciplinary teams. Present results to internal and external stakeholders.
* Regulatory Compliance: Ensure all in vivo studies are conducted in compliance with regulatory guidelines (e.g., GLP, ICH, FDA) and ethical standards, including proper animal welfare practices.
* Collaboration: Work closely with other departments, such as medicinal chemistry, biochemistry, and clinical development, to drive the progression of drug candidates through the preclinical pipeline.
* Continuous Learning: Stay updated with the latest trends and innovations in in vivo pharmacology and pharmacokinetics, contributing to the development of best practices and new methodologies.
Qualifications:
* Education: Ph.D., M.S., or equivalent in Pharmacology, Toxicology, Biology, or a related field.
* Experience:
* For Ph.D. candidates: At least 2-4 years of post-doctoral or industry experience in in vivo pharmacology.
* For M.S. candidates: 4-6 years of experience in an in vivo pharmacology or preclinical development role.
* Technical Skills:
* Proficiency in designing and conducting in vivo pharmacology studies (e.g., dosing, blood and tissue collection, behavioral assays).
* Experience with animal models for various therapeutic areas (oncology, immunology, cardiovascular, metabolic diseases, etc.).
* Strong knowledge of PK/PD modeling and associated laboratory techniques (e.g., ELISA, LC-MS/MS).
* Experience with data analysis software and tools (e.g., GraphPad, Excel, SPSS).
* Regulatory Knowledge: Familiarity with GLP, GxP, and other regulatory requirements for preclinical drug development.
* Communication Skills: Excellent written and verbal communication skills, with the ability to present complex scientific data clearly to a diverse audience.
* Collaboration: Strong team player with the ability to work cross-functionally in a fast-paced, collaborative environment.
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