In Roche’s Pharmaceutical Research and Early Development organization (p RED), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At p RED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed. The Position We are seeking a Laboratory Head to lead a Neuromuscular Research Group in the Neurotechnologies section within the Neuroscience and Rare Disease (NRD) therapeutic area. The primary focus of the section is on implementing and using novel delivery and RNA / DNA modifying techniques, as well as establishing suitable muscle disease models to develop therapeutics for some of the most challenging neuromuscular disorders. Our section works closely with other sections and groups within NRD as well as laboratories within our Therapeutic Modalities and Pharmaceutical Sciences groups and Data & Analytics to convert hypotheses into innovative therapeutics. Job mission We are offering an outstanding opportunity to lead a lab whose primary focus will be to establish in vitro models of muscle and neuromuscular diseases to better understand pathologies, test compounds, develop biomarkers, and suggest new therapeutic avenues. With a deep knowledge and experience in muscular and/or neuromuscular dystrophies, you will establish a new R&D working group in an exciting and fast-progressing therapeutic area. You will develop new therapeutic strategies and manage research programs in neuromuscular disorders. You will be responsible for applying scientific expertise and judgment to initiate, design, direct, and execute experiments and/or studies in support of research and/or development project goals in a time-sensitive manner. You will have tremendous resources and capabilities, and you will be surrounded by world-class scientists and drug hunters in a state-of-the-art new building located at the p RED center in Basel. Your key responsibilities Leading an effective team of Scientists and Associates to generate models of neuromuscular and muscular dystrophies. Bringing deep scientific expertise about neuromuscular and/or muscular pathologies, respective disease models, and an overview on therapeutic approaches in the preclinical and clinical space. Implementing cellular research models with endpoints that support understanding of patient disease and biomarkers. Leading drug discovery projects and ensuring successful translation of pre-clinical programs to a clinical setting. Preparing high-quality documents including technical reports, presentations, SOPs, and experimental protocols. Experience in regulatory filings is a plus. Acting as an impactful contributor and/or leader of project teams and seminal initiatives. Fostering creativity, productivity, execution with a sense of urgency, teamwork, accountability, cross-functional collaboration, and employee growth and development. Who you are You completed a Ph D or MD/Ph D in science and bring a minimum of 8 years solid research experience (after your Ph D) in the muscle biology or neuromuscular field. You bring a proven scientific track record through impactful publications in the field of muscle biology or neuromuscular disease, patents, or substantial contributions to drug development programs. Experience in drug development is a clear asset for the role. You are a rigorous scientist with strong expertise in cell-based and animal models of neuromuscular disease, including a solid grasp on the literature of disease mechanism and treatment avenues. You are driven by the desire to find therapeutics for some of the most devastating disorders. You possess excellent interpersonal and communication skills, enjoy teamwork, diligence, and efficiency. You have shown your capability to lead an independent research team. You are a kind and influential team leader and a trusted and knowledgeable colleague. You possess the flexibility to rapidly change priorities and deadlines and the ability to lead others through change in a dynamic, fast-paced industry and work environment. Working in a multicultural environment motivates you. Our commitment Roche commits to recognizing talent and aptitude. We prioritize encouraging and supporting our employees on their personal journeys by providing a safe, creative space to help them reflect, make decisions and grow in their career. We are confident that we find the most innovative solutions by gaining different perspectives, asking and answering hard questions, and challenging the status quo. Roche embraces diversity and equal opportunity in a serious yet enthusiastic way; we are devoted to building a team that represents a range of backgrounds, perspectives, and skills. The more inclusive we are, the better our work will be. Laboratory Head In Neuromuscular Disease • City, Switzerland
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