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PhD position on cartilage and osteochondral bioprinting for joint restoration, Basel
Client: The Biozentrum, University of Basel
Location: Basel
Job Category: Other
Job Reference: a911a49d2571
Job Views: 9
Posted: 21.01.2025
Expiry Date: 07.03.2025
Job Description:
Your position
The project aims to develop cartilage and osteochondral constructs using nasal chondrocytes (cells in clinical use for repairing cartilage defects) and Melt Electrowriting (MEW, an approach that combines electrospinning with 3D printing). In particular, the effect of scaffold architecture on nasal chondrocyte differentiation will be assessed. Additionally, the project aims to evaluate the regenerative capacity of the manufactured grafts in vivo using a temporomandibular joint defect model in animals.
The candidate is expected to:
1. Conduct CAD design, material optimization, and MEW scaffold printing.
2. Design and conduct in vitro experiments.
3. Explore the maturation of the grafts in vitro.
4. Generate the grafts for the animal study and analyze the regenerative tissues.
5. Generate scientific texts, including abstracts, publications, presentations, and protocols.
6. Supervise and teach BME/medical students.
Your profile
We seek a highly motivated candidate with:
1. MSc in Biomedical Engineering, Material Science, Biotechnology, Biology, or a similar field (required).
2. A background in musculoskeletal research, cell and molecular biology, biochemistry, or tissue engineering (strong advantage).
3. Experience with biomaterials, bioprinting, and Melt Electrowriting printing (hydrogels, polymers, mechanical test characterization).
4. Experience with cell and tissue culture, qPCR, immunoassays, viability assays, microscopy, or histology (strong advantage).
5. Excitement to work in a collaborative, interdisciplinary environment.
6. Independent thinking, ambition, focus on discovery, and dedication to perform research of the highest quality.
7. Excellent communication and writing skills in English.
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