We are looking for a Senior Specialist to lead the roadmap and implementation of the company in silico strategy and its integration to Next Generation Risk Assessment (NGRA) and work hand in hand with team specialists in Chemical Risk Assessment, PBPK, and other computational approaches. In addition, you will provide scientific risk assessment expertise to Nestlé R&D projects from inception through all stages of development (Safety by Design) with emphasis on computational toxicology applications for strategies considering in silico new approach methodologies (waiving, read-across, in silico predictions, molecular dynamics simulation, and Off-target binding identification) for risk assessment and the integration of in vitro and in silico methodologies for NGRA.
Aside from this, you will research strategies to speed up and improve chemical safety-based decision-making and inform risk management. Also, you will provide technical support to operations to manage food safety issues.
A Day in the Life of a Senior Specialist in Computational Toxicology
* Support the development and refine NGRA framework to assess the safety of Nestlé products (including e.g., novel ingredients) and mixtures lacking toxicological data.
* Lead the development and application of computational chemistry approaches to analyze data from high throughput in vitro assays, data from in vivo toxicity studies, chemical properties, and other relevant sources to develop predictive models for toxicity and physicochemical properties in applications for screening for the potential human health effects of chemicals.
* Develop/implement new approaches in Risk Assessment, to support R&D projects and management of issues in operations. Demonstrate widely recognized competences in in silico toxicology and its application in food risk assessment.
* Lead the roadmap and implementation of the in silico strategy and its integration to NGRA.
* Lead projects, project streams, and safety relevant activities in new product development projects (NR, NPTCs, and R&D centers). This includes the planning, management, and interpretation of externally contracted activities.
* Provide evaluations and propose strategies for molecules (from new ingredients, food contact materials, contaminants, plant toxins) without toxicological data in response to operational issues, crisis, and Early Warning.
* Develop and integrate key knowledge area and expertise into business.
* Develop tools in the domain of food risk assessment through research projects and contributions to expert groups.
What will make you successful
* PhD in Natural Sciences/Toxicology or Chemo-informatics; Postdoc(s) would be an asset.
* Profound knowledge and experience in research and application of computational toxicology tools to support the risk assessment of chemicals in food.
* Experience in toxicology in the context of R&D.
* Experience in risk assessment of chemicals and bioactive compounds in foods and other areas (packaging, chemical contaminants, supplements, new ingredients), and integration of in vitro/in silico approaches.
* Previous exposure to alternatives to animal testing (in vitro/in silico approaches).
* Experience in contributing/chairing international expert groups.
* Strength in communication (written and oral), collaboration/cooperation, and networking. Coaching of junior colleagues.
* Good written and oral communication in English.
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