Inborn errors of metabolism are rare but life-threatening diseases, usually presenting in the newborn or childhood period. The Division of Metabolism at the University Children's Hospital is a leading diagnostic centre and treatment centre for many metabolic diseases.
We aim to develop novel diagnostic methods and treatments for these devastating disorders. Our research involves re-growing a large biobank of patient-derived fibroblasts and developing multi-omics based diagnostic assays with potential for rapid clinical translation.
Our previous work demonstrated that multi-omics analysis provides a higher diagnostic rate than conventional biochemical or genomics-based diagnosis alone. We will re-evaluate this approach for multiple new diseases by preparing patient-derived fibroblasts from our biobank for measurement using state-of-the-art genomic, transcriptomic, proteomic, and metabolomic methods.
Your Responsibilities:
* Perform cell culture work efficiently and prepare samples for measurement
* Work closely with a senior expert in cell culture for quantitative high-throughput experiments
* E nsure diligent, reproducible, and well-documented work to guarantee high-quality samples
* Contribute to creating a unique data resource for diagnosing children with rare inherited diseases
Your Profile:
* Hold a Master's degree in biochemistry, molecular biology, or a related field, or equivalent experience as a lab technician
* Demonstrate a solid background in laboratory work with proven experience
* Show strong motivation and team player skills
* Have hands-on experience with human cell culture and experience in high-throughput cell culture and sample preparation for quantitative experiments
* Show interest in rare diseases and their clinical translation
This position comes with a competitive salary between CHF 80'000 and CHF 90'000 per year.