Postdoctoral Fellow in Jinghui Group at Paul Scherrer Institute
The Paul Scherrer Institute (PSI) is a leading research institution for natural and engineering sciences within Switzerland.
We conduct cutting-edge research in various fields, including future technologies, energy and climate, health innovation, and the fundamentals of nature.
Our goal is to develop sustainable solutions for significant societal challenges through fundamental and applied research.
About Our Research
The team combines X-ray techniques with cryo-EM and single nanopore methods to investigate protein dynamics, nanoclusters, and aggregation related to neurodegeneration.
Our focus has expanded from experimental characterization to include in vitro and in vivo correlation studies using C. elegans and mammalian cells as models.
We utilize RNAi to explore the potential of molecular glues for amyloid protein degradation.
About Your Role
This role involves creating novel molecular glues through in vitro biophysical techniques using C. elegans or cell models to investigate their potential for protein degradation.
Requirements
* A Ph.D. in Biochemistry, Biophysics, Cell Biology, or a related field
* Experience with expressing and purifying amyloid proteins, including biochemical and biophysical characterization
* Strong analytical and critical thinking skills for addressing complex scientific challenges
* Excellent organizational skills and attention to detail
* A passion for scientific research with a proactive approach to new challenges
About Your Work Environment
You will work within the Center for Life Sciences at PSI, which provides access to state-of-the-art facilities, including high-performance computing, cryo-EM, single-nanopore sensing, mass spectrometry, and other biophysical instruments.
We Offer
A dynamic and interdisciplinary collaboration environment, systematic job training, personal development opportunities, and modern employment conditions that support your optimal combination of work and family life or other personal interests.