Postdoc Function of Cytokines in Regulating Mammalian Hematopoietic Stem and Progenitor Cell Fates
The Cell Systems Dynamics group studies cell fate choices and their molecular control in complex and dynamic mammalian cell systems.
In the project advertised here, we are interested in the function of cytokines in regulating mammalian hematopoietic stem and progenitor cell fates.
We will use a combination of stem cell purification, culture and manipulation, long-term live cell imaging, single cell tracking and quantification, large volume 3D bone marrow imaging with single molecule sensitivity, and AI-supported computational analysis.
We are seeking a highly motivated postdoc with expertise in molecular and cellular biology, mammalian blood stem and progenitor cell purification, culture and manipulation, and advanced imaging to join our interdisciplinary team.
Key Responsibilities
* Quantitative in situ and in vitro imaging studies related to cytokine signaling and cell-cell interactions.
* Design and optimization of multiplexed fluorescence imaging, in situ single-molecule detection, and 3D immunofluorescence techniques.
* Primary human and mouse stem cell cultures and lentiviral manipulations to study hematopoietic stem cell dynamics.
* Primary mammalian tissue handling: isolation, fixation and vibratome sectioning for immunostaining.
* AI-assisted image analysis for spatial analysis of tissue samples.
* Multidisciplinary teamwork with immunologists, data scientists, and bioengineers to integrate imaging-based techniques into immunotherapy development.
* Presentation and publication of research findings.
* Supervision of junior researchers to provide technical and scientific training in advanced imaging and molecular techniques.
* Contribution to undergraduate student teaching.
Profile
Required Qualifications:
* Ph.D. in Biotechnology, Immunology, Molecular Biology, Stem Cell Biology or a related field.
* Published expertise in:
o Mammalian hematopoietic stem cell biology, purification, culture and manipulation.
o Molecular biology.
o Lentivirus cloning and production.
o Live-cell biosensor cloning and use for quantification of cytokine signaling dynamics.
o Long-term fluorescence live-cell imaging, single cell tracking and quantification.
o Large volume multi-color 3D imaging.
o Quantitative computational image analysis.
* Track record of high-impact publications.
* Experience in teaching (lectures and practical courses).
* Experience in Good Laboratory Practice (GLP) and Biosafety Level 2 (BSL2) work.
* LTK qualification for mouse work in Switzerland.
Workplace
ETH Zurich offers a career with impact: Become part of ETH Zurich, which not only supports your professional development but also actively contributes to positive change in society. In line with our values, ETH Zurich encourages an inclusive culture. We promote equality of opportunity, value diversity and nurture a working and learning environment in which the rights and dignity of all our staff and students are respected. Visit our Equal Opportunities and Diversity website to find out how we ensure a fair and open environment that allows everyone to grow and flourish.
Curious? So are we.
We look forward to receiving your online application with the following documents:
* CV including information on the required qualifications listed above.
Please note that we exclusively accept applications submitted through our online application portal. Applications via email or postal services will not be considered.
Further information about the Department of Biosystems Science and Engineering can be found on our website www.webseite.ethz.ch. Questions regarding the position should be directed to Prof. Timm Schroeder, email timm.schroeder@bsse.ethz.ch (no applications).
ETH Zurich is one of the world’s leading universities specializing in science and technology. We are renowned for our excellent education, cutting-edge fundamental research and direct transfer of new knowledge into society. Over 30,000 people from more than 120 countries find our university to be a place that promotes independent thinking and an environment that inspires excellence. Located in the heart of Europe, yet forging connections all over the world, we work together to develop solutions for the global challenges of today and tomorrow.
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